I made the trip in reverse back in 2003. Wilmington to Dana Point. We left Colonial Boat Yard at 0800, stopped in Newport for lunch at 1200. Pulled into the slip in Dana Point around 1600. Of course we had the good fortune of good wind and the current at about 1.5 knots.
Leaving in the early morning is a great idea if you plan on motoring. Calm waters and little wind.
Be safe and enjoy the trip.
Sam
Northstar 86' 32-3
Dana Point