Hi,
I single hand a lot on our E30+, and I have disabled our auto pilot because when I'm on the boat I want to sail her, not have some machine do it for me!
I do have all lines led aft, though I have to go forward to put the cringle around the hook at the gooseneck to add a single or double reef. When I first got our boat, I replaced any stiff lines that would impede tacking or raising sails, and shortened any that were too long, so I only have the required length, not extra line to trip over.
When I prepare to tack, I ensure the working jib sheet will let loose and not jam, and the lazy jib sheet is on the winch ready to be trimmed. If I am close hauled and the wind direction allows me to keep the boom centred on the boat, I don't have to adjust the mainsail which makes it really easy. Otherwise, I sometimes move the traveller/mainsheet to where I anticipate I'll want it, and if necessary, tweak it a bit after the tack; it's also possible to let the jib come across, trim it and adjust the mainsail afterwards. Other adjustments, like outhaul, boom vang, back stay adjuster, etc. are done between tacks. I also try to tack in a smooth turning motion, so everything has time to find it's new place, rather than a sudden jerky tack.
When jibing, I will open the mainsheet chock and have the mainsheet in my hand. As I begin the jibe turn, I'll pull in on the boom, bringing it to centre and as soon as the wind begins to fill the sail I'll let the mainsheet out, so it's a controlled motion. After closing the chock, I'll tack the headsail and trim it. If the wind is very light, I can do both sails at the same time--not as hard as it sounds.
It's important to set the boat up so you can reach lines, winches, etc, and then to practice in lighter air til you develop your preferred approach.
Good luck!
Frank